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KMID : 0363320060270020336
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 2 p.336 ~ p.344
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Comparative study of 202 herbs on interferon-gamma secretion
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Rhee See-Hyung
Kang Mi-Suk
Choi You-Kyung
Jeon Chan-Yong
Park Jong-Hyung
Kim Dong-Woo
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Abstract
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Objects : This study has been carried out to assess the effects of the variable herbs on IFN-{gamma} secretion in the mouse spleen cell.
Methods : 202 kinds of herb extracts were used to evaluate the IFN-{gamma} secretory distinction by each 1{mu}g/ml and 10{mu}g/ml density of water. All experimental herbs were grouped by oriental herbalogical method. But each herb had its independent variables.
Results : The secretions increased in 20% of all herbal water. The density differences also make different effects on the secretion of IFN-{gamma}. The secretion of IFN-{gamma} inclosed in some kinds of herbs of IFN-{gamma}. It has representatively increased in Imperaetae Rhizoma(ÛÜÙÆÐÆ) of 1{mu}g/ml and Notopterygii Rhizoma(˶üÀ)of 10{mu}g/ml. IFN-{gamma} incresed in 12 kinds of heybs of both densities. The secretion of IFN-{gamma} decreased in some kinds of herbs of IFN-{gamma}. It has representatively decreased in Moutan Radicis Cortex(áÌÓ¡ù«) of 1{mu}g/ml and Angelicae Radix(Ý£ÏýÚ) of 10{mu}g/ml. IFN-{gamma} decreased in 18 kinds of herbs of both densities. In t oriental herb group, The secretion of IFN-{gamma} increased in Bang-Hyang-Hwa-Sup group(Û»úÅûùã¥å·), He-Pyo group(ú°øúå·), I-Su-Sam-SuP group(ì¦â©ß¶) The secretion of IFN-{gamma} decreased in Gu-Chung group(ÏÌõùå·), An-Sin group(äÌãêå·). Su-Sap group(â¥ß») On-Li group(è®×êå·), I-Gi group(ì¦Ñ¨å·).
Conclusions : The result of this study will not only broaden applications of oriental medicine to biological therapy, but also form the basis of oriental medical therapy to find out the meaning of oriental classification.
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KEYWORD
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interferon gamma, IFN-{gamma}, mouse, spleen, Oriental Herb, screening
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